If they are headed to Cairo, make sure she checks with the state depts. website for travel advisories.
Its probably wise to stay with a large tour group instead of doing a self guided tour.
I havent been there for fifteen years, but our group hired a local guide. Saw the Cairo museum and went into the queens chamber in the Great Pyramid at Giza, which is just outside the city along with the Sphinx and two other pryramids.
Tell her to see the Great Pyramid at night the first time. They have a free show complete with lights and loudspeakers. Pretty awe inspiring to see it for the first time as it appears out of the dark sky when the lights hit it during the show.
Put in your order for an eighteen carat gold Kartouch with your wifes name in egyptian heiroglyphics. Pretty neat.
The only problem I had with Egypt is the smell. Eau de Camel Dung.